Studies on Chemotherapeutics. II

Antifungal chemotherapeutics.

This review addresses trends in outcome and risk factors for invasive fungal infections, current antifungal agents and new therapeutic strategies. Current prospects for new therapies rest upon caspofungin, the first of a new class of antifungal molecules, the echinocandins, and new extended-spectrum azoles, voriconazole, posaconazole and ravuconazole. Approval by the Food and Drug Administratio...

Chiral discrimination of metal – based chemotherapeutics Co ( II ) , Cu ( II ) and Zn ( II ) towards the ultimate drug target – DNA

Understanding the interaction of pharmaceutical agents to DNA is essential for underlying their mode of action, site, sequence and structural specificity of their binding reactions. Chirality of a complex is a pre–requisite criterion for an appropriate model drug design, since usually two enantiomers of the same metal complex have different binding constants and recognition properties. Interact...

Nanoformulations of Antimicrobial Chemotherapeutics

Bacterial infections represent an increasing worldwide threat. The number of untreatable diseases decreased after the 1950s due to the introduction of antimicrobial agents. However, since the 1980s, morbidity has risen again, and mortality due to respiratory infections, AIDS and tuberculosis now represents about 85% of world mortality from infections [1,2]. The increase in the number of new inf...

Integrin Targeted Delivery of Chemotherapeutics

Targeted delivery of chemotherapeutics is defined in the sense, that is, to maximize the therapeutic index of a chemotherapeutic agent by strictly localizing its pharmacological activity to the site or tissue of action. Integrins are a family of heterodimeric transmembrane glycoproteins involved in a wide range of cell-to-extracellular matrix (ECM) and cell-to-cell interactions. As cell surface...

Studies on Echinococcosis : Ii. Echinococcosis in Japan